Name: Glutathione
Brand: Amino Club
SKU: Glutathione - 1500MG
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Frequently Asked Questions

Common questions about glutathione research

Glutathione (GSH) is a tripeptide composed of glutamate, cysteine, and glycine that's found in every cell of the body. It's called the 'master antioxidant' because it directly neutralizes free radicals, regenerates other antioxidants (vitamins C and E), and is essential for the body's detoxification systems. GSH participates in over 500 enzymatic reactions and maintains cellular redox balance.

Yes. While it was previously believed that oral GSH was poorly absorbed, a landmark 6-month randomized controlled trial demonstrated that daily oral GSH supplementation (250-1000mg) significantly increased glutathione levels in blood, erythrocytes, plasma, lymphocytes, and buccal cells. The high-dose group showed 30-35% increases in most compartments and a remarkable 260% increase in buccal cells. These findings confirmed oral GSH bioavailability in humans.

Clinical trials have demonstrated several benefits: (1) Increased tissue glutathione stores by 30-260% depending on tissue type; (2) More than doubled Natural Killer cell cytotoxicity, indicating enhanced immune function; (3) Improved insulin sensitivity in obese subjects with and without diabetes; (4) Reduced skin melanin indices in multiple body sites; (5) Decreased liver enzymes (ALT) in NAFLD patients. Benefits were dose-dependent and accumulated over time.

Clinical trials have used doses ranging from 250mg to 1000mg daily. The 6-month RCT showed that both doses were effective, but 1000mg produced greater and faster increases in tissue GSH levels. Benefits were seen by 1 month and continued to increase through 6 months. Some protocols divide the daily dose into two administrations. Liposomal formulations may enhance absorption at lower doses.

Oral glutathione has demonstrated an excellent safety profile in clinical trials lasting up to 6 months. In the landmark RCT, 100% of participants completed the study with no dropouts due to adverse effects. Both low-dose (250mg) and high-dose (1000mg) were well-tolerated. However, IV glutathione has different safety considerations — the FDA has received adverse event reports with compounded IV GSH, and it's not approved for any indication including skin lightening.

Clinical trials showed measurable increases in tissue glutathione levels within 1 month of supplementation, with continued improvements through 6 months. NK cell cytotoxicity more than doubled by 3 months in the high-dose group. Importantly, when supplementation stopped, levels returned to baseline within 1 month — indicating that ongoing supplementation is needed to maintain elevated GSH stores.

Glutathione is the direct antioxidant molecule, while NAC is a precursor that provides cysteine (the rate-limiting amino acid for GSH synthesis). NAC has extensive clinical data and supports the body's own GSH production. Direct GSH supplementation has the advantage of not requiring metabolic conversion, but NAC has better-established long-term safety data. Some practitioners use both approaches.

A randomized, placebo-controlled trial found that oral GSH (500mg/day for 4 weeks) decreased melanin indices at all six measured body sites, with statistically significant reductions on the face and sun-exposed forearm. However, the researchers noted that long-term safety for this use hasn't been established. IV glutathione for skin lightening is NOT recommended due to safety concerns flagged by the FDA and other regulatory bodies.

Glutathione

Frequently Researched Together

GHK-Cu

NAD+

Antioxidant Defense

Phase II Detoxification

Redox Regulation

GSH Increase by Tissue Type (1000mg/day, 6 months)

Key Trial Results

Oxidative Stress Protection

Natural Killer Cell Support

Insulin Sensitivity

Standard Oral Protocol

IV Glutathione Protocol

Pharmacokinetic Properties

⚠️Important Notes

GI discomfort

Bloating

Headache

IV Administration Concerns

Trial Completion Rates

💡Researcher Notes

Glutathione Structure

Key Enzyme Systems

Stability Information

What is glutathione and why is it called the 'master antioxidant'?

Does oral glutathione actually get absorbed?

What are the proven benefits of glutathione supplementation?

How much glutathione should be taken?

Is glutathione safe?

How long does it take to see effects from glutathione?

What's the difference between glutathione and NAC (N-acetyl cysteine)?

Can glutathione lighten skin?

Randomized controlled trial of oral glutathione supplementation on body stores of glutathione

Glutathione as an oral whitening agent: a randomized, double-blind, placebo-controlled study

The effects of 3 weeks of oral glutathione supplementation on whole body insulin sensitivity in obese males with and without type 2 diabetes

Efficacy of glutathione for the treatment of nonalcoholic fatty liver disease: an open-label, single-arm, multicenter, pilot study

Glutathione metabolism and its implications for health

Glutathione Compound Summary

Oral supplementation with liposomal glutathione elevates body stores of glutathione and markers of immune function

FDA highlights concerns with using dietary ingredient glutathione to compound sterile injectables

⚠️Important Research Notice

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Frequently Researched Together

GHK-Cu

NAD+

Important Notes

Researcher Notes