Name: SEMAX
Brand: Amino Club
SKU: SEMAX - 10MG
Availability: InStock
Rating: 4.9 (84 reviews)

SEMAX | 99%+ Pure Peptide | Amino Club | Amino Club

Dosing Information from Research

From clinical use in Russia and preclinical studies

Semax is administered intranasally in Russia as a 0.1% solution for cognitive enhancement or 1% solution for stroke treatment. The Pro-Gly-Pro extension increases the duration of effects to 20-24 hours compared to native ACTH fragments.

Clinical Protocol

Standard Nootropic Protocol

Russian approved formulation for cognitive enhancement

1-14DAY

200-600 mcg

2-3x daily intranasal

0.1% solution (2-3 drops per nostril)

0.1% solution standard for cognitive enhancement

Total daily dose: 400-1,800 mcg

Treatment duration: typically 10-14 days

Cycles may be repeated after 2-4 week break

Neuroprotection Protocol

Stroke Recovery Protocol

Higher concentration for neuroprotection

1-10DAY

2,000-6,000 mcg

3-4x daily intranasal

1% solution for stroke treatment

1% solution used for stroke and severe cognitive impairment

Higher doses for acute neuroprotection

Combined with rehabilitation therapy

Medical supervision required

Research Protocol

Preclinical studies dosing

SingleDOSE

50 mcg/kg

Single intranasal

Effective dose in animal studies

50 mcg/kg showed significant BDNF upregulation

Intranasal route preferred for CNS delivery

Effects observed within hours

Duration: 20-24 hours

Pharmacokinetics

Pharmacokinetic Properties

Half-life (plasma)1-2 hours

Duration of EffectExtended by Pro-Gly-Pro modification20-24 hours

AdministrationIntranasal or subcutaneous

Oral BioavailabilityPoor (peptide)

Blood-Brain BarrierCrosses readily (intranasal)

Pro-Gly-Pro C-terminal extension provides metabolic stability

Effects last 20-24 hours despite short plasma half-life

Intranasal administration optimal for CNS delivery

Poor oral bioavailability typical for peptides

Important Notes

Research protocols only — approved only in Russia
Intranasal administration preferred for rapid CNS effects
Pro-Gly-Pro modification extends duration vs. native ACTH
No tolerance development reported in clinical use
Consider cycling with 2-4 week breaks between courses

Frequently Asked Questions

Common questions about Semax research

Semax is a synthetic heptapeptide (7 amino acids: Met-Glu-His-Phe-Pro-Gly-Pro) developed at the Institute of Molecular Genetics of the Russian Academy of Sciences. It's an analog of ACTH (4-10), the adrenocorticotropic hormone fragment responsible for cognitive effects. The C-terminus was extended with Pro-Gly-Pro to enhance metabolic stability and prolong its duration of action from minutes to 20-24 hours.

While Semax is derived from ACTH (4-10), it lacks the hormonal activity of the parent hormone. ACTH stimulates the adrenal cortex to produce cortisol, but Semax does not affect the hypothalamic-pituitary-adrenal (HPA) axis. Semax retains the nootropic and neuroprotective properties of ACTH fragments without causing hormonal side effects, making it suitable for cognitive enhancement applications.

Research demonstrates that Semax increases BDNF protein levels by 1.4-fold and BDNF mRNA by 3-fold in the hippocampus. It also increases TrkB receptor phosphorylation by 1.6-fold. In clinical use in Russia, Semax has shown efficacy in stroke recovery, improving motor function and functional recovery when combined with rehabilitation. Animals treated with Semax show improved learning and memory in conditioned avoidance tests.

Semax has been approved in Russia since the 1990s for treating ischemic stroke, traumatic brain injury, and cognitive impairment. It's available as 0.1% nasal drops for cognitive enhancement and 1% solution for stroke treatment. It is not approved by the FDA in the United States or by regulatory agencies in most Western countries, where it remains classified as a research compound.

Semax is administered intranasally as the preferred route for CNS delivery. In Russian clinical practice, the standard protocol uses 0.1% solution (2-3 drops per nostril, 2-3 times daily) for cognitive enhancement, with treatment courses of 10-14 days. For stroke treatment, a 1% solution is used at higher doses. The intranasal route provides good bioavailability and direct access to the brain.

Semax and Selank are both Russian-developed peptides but have different origins and mechanisms. Semax is an ACTH (4-10) analog primarily targeting BDNF/TrkB pathways for cognitive enhancement and neuroprotection. Selank is a tuftsin analog that modulates the GABAergic system for anxiolytic effects. Semax is more focused on cognitive enhancement and stroke recovery, while Selank is more anxiolytic. Both are approved in Russia and can be used together.

Semax has been used clinically in Russia for over 30 years with a favorable safety profile. Unlike ACTH, it does not affect cortisol levels or the HPA axis. Reported side effects are generally mild and include occasional nasal irritation, mild headache, and transient dizziness. No dependence, tolerance, or withdrawal symptoms have been reported. However, Western clinical trial data is limited, and long-term safety studies in Western populations are lacking.

The Pro-Gly-Pro (PGP) extension at the C-terminus of Semax provides protection against peptidase degradation, extending its duration of action from minutes (native ACTH 4-10) to 20-24 hours. This modification was specifically designed in the 1970s to create a more practical cognitive enhancer that could be administered once or twice daily rather than requiring continuous infusion.

SEMAX

Frequently Researched Together

GHK-Cu

NAD+

SELANK

Neurotrophic Enhancement

BDNF/TrkB Pathway

Melanocortin System

Vascular Gene Expression

BDNF Upregulation

Neuroprotective in Ischemia

BDNF/TrkB System Activation

Key Findings from Studies

Nootropic Effects

Stroke Recovery Support

Angiogenesis Support

Adaptive Regulation

Standard Nootropic Protocol

Stroke Recovery Protocol

Research Protocol

Pharmacokinetic Properties

⚠️Important Notes

Nasal Irritation

Mild Headache

Dizziness

Taste Disturbance

No Hormonal Effects

Tolerability in Clinical Use

Research Considerations

💡Researcher Notes

What Is Semax?

Stability Information

Regulatory Information

What is Semax and where does it come from?

How does Semax differ from ACTH?

What does the research show about Semax?

Is Semax approved for medical use?

How is Semax typically administered in research?

How does Semax compare to Selank?

Is Semax safe?

Why does Semax last longer than native ACTH fragments?

Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus

The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia

The efficacy of semax in the treatment of patients at different stages of ischemic stroke

Comparison of the temporary dynamics of NGF and BDNF gene expression in rat hippocampus, frontal cortex, and retina under Semax action

Novel Insights into the Protective Properties of ACTH(4-7)PGP (Semax) Peptide at the Molecular Level

Semax - Cognitive Vitality For Researchers

Semax - Compound Summary (CID 9811102)

⚠️Important Research Notice

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Frequently Researched Together

GHK-Cu

NAD+

SELANK

Important Notes

Researcher Notes