Name: SELANK
Brand: Amino Club
SKU: SELANK - 10MG
Availability: InStock
Rating: 4.9 (89 reviews)

SELANK | 99%+ Pure Peptide | Amino Club | Amino Club

Frequently Asked Questions

Common questions about Selank research

Selank is a synthetic heptapeptide (7 amino acids: Thr-Lys-Pro-Arg-Pro-Gly-Pro) developed at the Institute of Molecular Genetics of the Russian Academy of Sciences. It's derived from tuftsin, a naturally occurring immunomodulatory tetrapeptide found in the Fc region of immunoglobulin G (IgG). The C-terminus was extended with Pro-Gly-Pro to enhance metabolic stability and prolong its duration of action.

While both Selank and benzodiazepines reduce anxiety through the GABAergic system, they work differently. Benzodiazepines directly bind to specific benzodiazepine sites on GABA-A receptors, causing sedation, memory impairment, and physical dependence. Selank allosterically modulates GABA-A receptors without these side effects. Clinical trials show comparable anxiolytic efficacy but Selank also has antiasthenic (anti-fatigue) and psychostimulatory effects, plus cognitive enhancement rather than impairment.

A key randomized controlled trial studied 62 patients with generalized anxiety disorder (GAD) and neurasthenia, comparing intranasal Selank (30 patients) to oral medazepam (32 patients) for 14 days. Both showed similar anxiolytic effects on Hamilton, Zung, and CGI scales, but Selank also demonstrated antiasthenic and psychostimulatory properties. Importantly, Selank increased enkephalin activity in blood serum, correlating with anxiety reduction. No sedation, dependence, or withdrawal was observed.

Selank was approved by the Russian Federation Ministry of Health in 2009 and is available by prescription in Russia and Ukraine as a 0.15% intranasal solution for the treatment of generalized anxiety disorder. It is not approved by the FDA in the United States or by regulatory agencies in most other countries, where it remains classified as a research compound.

In clinical trials, Selank is administered intranasally as a 0.15% solution. The standard protocol is 2 drops (75 mcg per drop) in each nostril, 3 times daily for 14 days (total ~1,350 mcg/day). Some studies used up to 2,700 mcg/day for 21 days. The intranasal route provides 92.8% bioavailability and optimal delivery to the CNS. Due to its short plasma half-life (2-3 minutes), multiple daily doses are necessary.

Selank demonstrates nootropic (cognitive-enhancing) properties alongside its anxiolytic effects. Research shows it upregulates BDNF (brain-derived neurotrophic factor), a key protein for learning, memory, and neural plasticity. In one study, Selank protected against ethanol-induced memory impairment by normalizing BDNF levels in the hippocampus and prefrontal cortex. It also modulates serotonin and dopamine, neurotransmitters crucial for mood and cognition.

Selank has an excellent safety profile in clinical studies. It breaks down into natural amino acids in the body. Unlike benzodiazepines, it causes no sedation, amnesia, cognitive impairment, muscle relaxation, tolerance, or physical dependence. Reported side effects are minimal — occasional mild nasal irritation, transient headaches in the first few days, and vivid dreams early in treatment. No serious adverse events have been reported in published studies.

Research suggests Selank may enhance the effects of benzodiazepines when used together. One study showed that combining Selank with diazepam was more effective at reducing anxiety than either alone, suggesting Selank may increase benzodiazepine receptor affinity. However, drug interactions are not extensively characterized, and combination use should only occur under appropriate research protocols or medical supervision in jurisdictions where it is approved.

SELANK

Frequently Researched Together

GHK-Cu

NAD+

DSIP

SEMAX

Anxiolytic Without Sedation

GABAergic System

BDNF Pathway

Enkephalin System

GABA Without the Downsides

Anxiolytic + Nootropic

Selank vs. Benzodiazepine Comparison

Key Safety & Efficacy Findings

Nootropic Effects

Adaptive Stress Regulation

Immunomodulatory Properties

Brain Health Support

Standard Clinical Protocol

Research Protocol (Higher Dose)

Weight-Based Research Protocol

Pharmacokinetic Properties

⚠️Important Notes

Nasal Irritation

Mild Headache

Vivid Dreams

Throat Irritation

No Benzodiazepine Side Effects

Tolerability in Clinical Trials

Research Considerations

💡Researcher Notes

What Is Selank?

Stability Information

Regulatory Information

What is Selank and where does it come from?

How is Selank different from benzodiazepines?

What does the clinical research show?

Is Selank approved for medical use?

How is Selank typically administered in research?

What cognitive benefits has Selank shown?

Is Selank safe?

Can Selank be combined with other medications?

Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia

Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats

Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission

Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats

A comparison of the anxiolytic effect and tolerability of selank and phenazepam in the treatment of anxiety disorders

The inhibitory effect of Selank on enkephalin-degrading enzymes as a possible mechanism of its anxiolytic activity

The Influence of Selank on the Level of Cytokines Under Conditions of Experimental Immunodeficiency

Selank Intranasal Bioavailability Studies

Selank - Compound Summary

⚠️Important Research Notice

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Frequently Researched Together

GHK-Cu

NAD+

DSIP

SEMAX

Important Notes

Researcher Notes