Name: Thymosin Alpha-1
Brand: Amino Club
SKU: Thymosin Alpha-1 - 10MG
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Thymosin Alpha-1 | 99%+ Pure Peptide | Amino Club | Amino Club

Frequently Asked Questions

Common questions about Thymosin Alpha-1 research

Thymosin Alpha-1 is a 28-amino acid peptide naturally produced by the thymus gland — the organ responsible for T cell maturation and immune system education. It was first isolated from thymic tissue by Allan Goldstein at George Washington University. The synthetic version (thymalfasin/Zadaxin) is chemically identical to the human peptide and is approved in over 35 countries for hepatitis B and C treatment.

Thymosin Alpha-1 (as Zadaxin/thymalfasin) is not FDA approved in the United States, but it is approved in over 35 countries worldwide for the treatment of chronic hepatitis B and C. It has undergone Phase 2 and Phase 3 clinical trials in the US. It is widely used in Asia, Europe, and South America as both a standalone treatment and combination therapy with interferon.

Unlike simple immune stimulants, Thymosin Alpha-1 is a true immune modulator with bidirectional activity. It enhances immune function when suppressed (via TLR2/9 activation of dendritic cells and T cell maturation) while also activating regulatory pathways (IDO enzyme induction) to prevent harmful overactivation. This makes it useful in both immunosuppressed states (infections, aging, cancer) and conditions where immune balance is critical (sepsis, autoimmunity).

Beyond its approved indications for hepatitis B and C, Thymosin Alpha-1 has been studied in: sepsis and critical care (immune restoration), cancer (adjuvant to chemotherapy for HCC, NSCLC, RCC, melanoma), vaccine enhancement (particularly in elderly/immunocompromised), HIV (adjunctive therapy), COVID-19 (immune modulation in severe cases), mold toxicity, psoriatic arthritis, and age-related immune decline (immunosenescence).

Thymosin Alpha-1 has one of the most favorable safety profiles of any immune-modulating peptide. In clinical trials, many patients experienced no side effects at all. The most commonly reported effects were mild injection site reactions (redness, discomfort), transient joint aches, and local muscle atrophy at repeated injection sites. No serious adverse events have been attributed to the drug, and no drug interactions have been reported. It has been safely used in elderly and immunocompromised patients.

Thymosin Alpha-1

Frequently Researched Together

NAD+

Glutathione

Master Immune Regulator

Toll-Like Receptor 2/9

T Cell Maturation

NK Cell Enhancement

Dendritic Cell Programming

Immune Modulation, Not Just Stimulation

HBV DNA + HBeAg Clearance at 12-Month Follow-up

Response Rates Across Trials

Antiviral & Antibacterial

Improved Vaccine Response

Immune Senescence

Injection site reaction

Muscle atrophy (local)

Joint aches

Rash/swelling

Treatment Tolerability

Precautions

💡Researcher Notes

What Is Thymosin Alpha-1?

Stability Information

Where It Stands

What is Thymosin Alpha-1 and where does it come from?

Is Thymosin Alpha-1 FDA approved?

How does it differ from other immune boosters?

What conditions has it been studied for?

What are the side effects?

Thymosin alpha 1: A comprehensive review of the literature

Efficacy of thymosin alpha1 in patients with chronic hepatitis B: a randomized, controlled trial

Immune Modulation with Thymosin Alpha 1 Treatment

Thymosin α1 activates dendritic cell tryptophan catabolism and establishes a regulatory environment for balance of inflammation and tolerance

Zadaxin (thymalfasin) Drug Information

Thymalfasin | C129H215N33O55 | CID 16130571

Pharmacokinetics of thymosin alpha1 after subcutaneous injection of three different formulations in healthy volunteers

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Frequently Researched Together

NAD+

Glutathione

Researcher Notes