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⚠️ FOR RESEARCH PURPOSES ONLY — This compound is not FDA approved. All data presented is from clinical trials for educational reference.

SEMAX

Cognitive & Neuroprotective Peptide

SEMAX

4.9 (84 reviews)
ACTH (4-10)ACTH (4-7)-Pro-Gly-ProMet-Glu-His-Phe-Pro-Gly-ProMEHFPGPCAS: 80714-61-0

A 7-amino acid synthetic heptapeptide analog of ACTH (4-10) that upregulates BDNF expression and modulates the TrkB signaling pathway, studied for cognitive enhancement and neuroprotection in clinical research. Premium Research Peptide.

Dosage
Quantity
1
$29.99
Dosage
Quantity
1
$29.99
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Compound Information

Technical specifications

🧬Molecular Profile

What Is Semax?

Synthetic heptapeptide analog of ACTH (4-10) with C-terminal Pro-Gly-Pro extension for enhanced stability

HeptapeptideACTH Analog
TypeSynthetic heptapeptide
CAS Number80714-61-0
Molecular FormulaC37H51N9O10S
Molecular Weight813.9 g/mol
Amino Acids7 residues
SequenceMet-Glu-His-Phe-Pro-Gly-Pro
PubChem Database
🧊Storage Requirements

Stability Information

Handle with care to maintain potency

Light sensitiveTemperature sensitive
❄️
Lyophilized (powder)
-20°C•protect from light
💉
Reconstituted
2-8°C•use within 4 weeks
💉
Nasal spray
2-8°C•30 days after opening
📋Development Status

Regulatory Information

Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences

DeveloperRussian Academy of Sciences
ApprovalRussia (1990s)
IndicationsStroke, cognitive impairment
Formulations0.1% and 1% nasal spray
US StatusNot FDA-approved
Related PeptideSelank (tuftsin analog)
Wikipedia
📚

Sources & References

Peer-reviewed research

Brain Research

Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus

2006•DOI: 10.1016/j.brainres.2006.07.108•PMID: 16996037

Dolotov OV, Karpenko EA, Inozemtseva LS, et al.

View Source
BMC Genomics

The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia

2014•DOI: 10.1186/1471-2164-15-228•PMID: 24661656

Medvedeva EV, Dmitrieva VG, Povarova OV, et al.

View Source
Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova

The efficacy of semax in the treatment of patients at different stages of ischemic stroke

2018•PMID: 29798983
View Source
Journal of Molecular Neuroscience

Comparison of the temporary dynamics of NGF and BDNF gene expression in rat hippocampus, frontal cortex, and retina under Semax action

2010•DOI: 10.1007/s12031-009-9270-z•PMID: 19662538

Shadrina M, Kolomin T, Agapova T, et al.

View Source
International Journal of Molecular Sciences

Novel Insights into the Protective Properties of ACTH(4-7)PGP (Semax) Peptide at the Molecular Level

2020•PMID: 32575851
View Source
Alzheimer's Drug Discovery Foundation

Semax - Cognitive Vitality For Researchers

View Source
PubChem Database

Semax - Compound Summary (CID 9811102)

View Source

⚠️Important Research Notice

Not for human consumption. This product is sold exclusively for research and educational purposes. It is not intended to diagnose, treat, cure, or prevent any disease.

All clinical trial data and research findings presented on this page are sourced from peer-reviewed journals and official publications. They are provided for educational reference only and should not be interpreted as medical advice or product claims.

By purchasing this product, you confirm that you are a qualified researcher and will use it in accordance with all applicable laws and regulations.

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