Name: Epithalon
Brand: Amino Club
SKU: Epithalon - 10MG
Availability: InStock
Rating: 4.9 (34 reviews)

Epithalon | 99%+ Pure Peptide | Amino Club | Amino Club

Beyond Telomere Extension

Other benefits observed in research

Circadian

Rhythm ResetMelatonin synthesis & clock genes

Restored youthful melatonin patterns in aged monkeys

Goncharova et al. 2001

Immune

RecalibrationCD4+/CD8+ T cell ratio normalization

IL-2 upregulation and T cell rebalancing

Kazakova et al. 2002

DNA

Protection

Reduced chromosomal aberrations in aged mice

Rosenfeld et al. 2002

Tumor

Suppression

Reduced mammary tumor incidence in HER-2/neu mice

Anisimov et al. 2002

Circadian Health

Melatonin & Hormonal Restoration

Epithalon stimulates melatonin synthesis by upregulating AANAT and pCREB enzymes in pinealocytes, and restores youthful cortisol rhythms in aged primates.

Melatonin metabolite↑ 1.6-fold vs placebo

Cry2 gene expression↑ 2-fold

Clock gene expression↓ 1.8-fold

Cortisol rhythmNormalized in monkeys

Clinical finding: In a 75-woman randomized study, 20 days of sublingual Epithalon (0.5 mg/day) significantly modulated circadian gene expression.

Circadian Gene Study

Antioxidant Defense

Nrf2-Mediated Cellular Protection

Epithalon activates the Keap1/Nrf2 signaling pathway, boosting endogenous antioxidant enzyme expression and protecting cells from oxidative damage.

SOD-1 upregulation

+75%

Catalase expression

+70%

ROS reduction

+65%

Key result: In human skin fibroblasts, Epithalon reduced aging biomarkers p16 and p21, preserved mitochondrial integrity, and lowered oxidative damage markers.

Gutop et al. 2022

Neuroprotection

Cognitive & Neural Support

Early research shows Epithalon promotes neuronal differentiation, increases dendritic branching, and reduces oxidative DNA damage in neural cells.

sAPP secretion↑ ~20%

Dendritic length↑ Increased

8-OHdG (DNA damage)↓ Reduced

Nestin expression↑ Enhanced

Case study: A 79-year-old patient receiving Epithalon as part of combination therapy showed biological age reduction of 7.9 years and improved cognitive scores.

Kraskovskaya et al. 2024

Immune Modulation

Immunorejuvenation

Epithalon recalibrates immune function by upregulating IL-2 in aged tissues, increasing CD4+ T cells, and preserving CD8+ splenocyte homeostasis.

IL-2

Key Cytokine Upregulated

Research finding: Effects are age-dependent — Epithalon shows strongest immune recalibration in aged organisms, suggesting restorative rather than stimulatory action.

Labunets et al. 2004

Safety Profile from Research

What preclinical and early clinical studies report

Epithalon has demonstrated a favorable safety profile across published animal studies and small human trials. No serious adverse events have been reported in the literature. However, comprehensive long-term safety data in humans is limited.

Common Digestive Issues

Injection site irritation

mild

Mild headache

mild

Drowsiness

mild

Mild nausea

mild

Theoretical Consideration

Telomerase & Cancer RiskTelomerase activation is a double-edged sword

Epithalon (HER-2 mice)Reduced tumors

Untreated controlsHigher incidence

While Epithalon activates telomerase in somatic cells, unregulated telomerase activation could theoretically promote existing malignant cells. However, animal studies show Epithalon actually reduced tumor incidence.

HER-2/neu mice showed reduced breast tumor incidence with Epithalon
Colon carcinogenesis was inhibited in rat models
No tumor promotion has been observed in any published study
Context and dose appear critical for safety

Discontinuation Rates

Preclinical Safety Summary

5mg SC dailyNo dropouts reported

0.5mg sublingualNo dropouts reported

No serious adverse events reported in any published study

Well-tolerated across multiple animal species and small human studies

Long-term safety data (>1 year continuous use) is not available

Trial Exclusions

Important Considerations

Active malignancy (theoretical telomerase concern)Pregnancy or breastfeeding (not studied)Autoimmune conditions (immune modulation effects)Only all-L stereoisomer form has been studied

Regulatory Status

Not FDA-approved for any indication

Investigational research compound only

Included in FDA's 2023 list of 22 peptides with compounding restrictions

Approved for research use in Russia for over 30 years

Researcher Notes

No serious adverse events reported across all published studies
Animal studies spanning multiple species show consistent safety
Long-term human pharmacovigilance data is not yet available
Eight stereoisomeric forms exist — only all-L has been tested

Frequently Asked Questions

Common questions about Epithalon research

Epithalon (also spelled Epitalon) is a synthetic tetrapeptide with the amino acid sequence Ala-Glu-Asp-Gly (AEDG). It was developed by Professor Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology in Russia, based on a natural extract called epithalamin derived from the pineal gland of cattle. In 2017, researchers confirmed the presence of the AEDG peptide in native pineal gland extracts, validating its endogenous origin. It has been studied for over 30 years in Russian research programs.

Epithalon is not approved by the FDA for any medical indication. It is classified as a research compound. In 2023, the FDA included Epithalon in a list of 22 peptides with restrictions on compounding pharmacy use due to safety concerns. In Russia, it has been studied in clinical settings for over 30 years, including in registered clinical observations. No large-scale Phase 3 clinical trials have been conducted in Western regulatory frameworks.

Epithalon's most well-documented effect is telomerase reactivation in human somatic cells. In the landmark 2003 study by Khavinson et al., Epithalon induced expression of the telomerase catalytic subunit and enzymatic activity in human fetal fibroblasts, leading to telomere elongation. A follow-up study showed these treated cells exceeded the Hayflick limit, dividing 44 times vs. 34 in controls. In PHA-stimulated lymphocytes from adults aged 25-88, telomere length increased by an average of 33.3%, though results varied between individuals.

Most published research uses subcutaneous injection at 5-10mg daily for 10 consecutive days, cycled every 4-6 months. A randomized clinical study in 75 women used sublingual administration at 0.5mg/day for 20 days with significant circadian gene modulation results. Intranasal delivery has also been studied for CNS-related effects. Oral bioavailability is poor due to gut enzymatic degradation, making injection and sublingual routes preferred in research protocols.

Published studies report no serious adverse events across animal models and small human trials. Minor effects include injection site irritation, mild headache, and drowsiness (potentially from melatonin enhancement). The main theoretical concern is the dual nature of telomerase activation — while it promotes healthy cell division, it could theoretically support malignant cell growth. However, animal studies actually showed Epithalon reduced tumor incidence in HER-2/neu mice and inhibited colon carcinogenesis. Long-term safety data in humans is limited, and only one of eight stereoisomeric forms has been studied.

Lyophilized (freeze-dried) Epithalon should be stored at -20°C, protected from light, for up to 2 years. Once reconstituted, it should be refrigerated at 2-8°C and used within 30 days. Avoid repeated freeze-thaw cycles, which can degrade the peptide. The solution should appear clear — if cloudy or particulate, it should not be used.

Epithalon

Frequently Researched Together

GHK-Cu

NAD+

DSIP

SELANK

Glutathione

Multi-Pathway Geroprotector

Telomerase Activation

Pineal / Circadian

Epigenetic Modulation

Antioxidant Defense

Telomerase Reactivation in Human Cells

Cell Replicative Lifespan: Epithalon vs Control

Key Findings Across Studies

Circadian Gene Modulation (Human Study)

Animal Lifespan Extension Studies

Melatonin & Hormonal Restoration

Nrf2-Mediated Cellular Protection

Cognitive & Neural Support

Immunorejuvenation

Injection site irritation

Mild headache

Drowsiness

Mild nausea

Telomerase & Cancer RiskTelomerase activation is a double-edged sword

Preclinical Safety Summary

Important Considerations

💡Researcher Notes

What Is Epithalon?

Stability Information

Where It Stands

What is Epithalon and where does it come from?

What is the regulatory status of Epithalon?

What does the research show about telomerase activation?

How is Epithalon administered in research?

What are the safety concerns with Epithalon?

How should Epithalon be stored?

Overview of Epitalon — Highly Bioactive Pineal Tetrapeptide with Promising Properties

Epithalon Peptide Induces Telomerase Activity and Telomere Elongation in Human Somatic Cells

Peptide Promotes Overcoming of the Division Limit in Human Somatic Cells

Effect of Peptide AEDG on Telomere Length and Mitotic Index of PHA-Stimulated Human Blood Lymphocytes

AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism

Effect of Epitalon on the Lifespan Increase in Drosophila melanogaster

Effect of Synthetic Thymic and Pineal Peptides on Biomarkers of Ageing, Survival and Spontaneous Tumour Incidence in Female CBA Mice

Regulatory Effect of Epithalon on Production of Melatonin and Cortisol in Old Monkeys

Inhibitory Effect of the Peptide Epitalon on the Development of Spontaneous Mammary Tumors in HER-2/neu Transgenic Mice

Improving Biological Age, Telomere Length, and Cognition: A Case Study

Molecular Cellular Mechanisms of Peptide Regulation of Melatonin Synthesis in Pinealocyte Culture

AEDG Peptide Prevents Oxidative Stress in the Model of Induced Aging of Skin Fibroblasts

⚠️Important Research Notice

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Frequently Researched Together

GHK-Cu

NAD+

DSIP

SELANK

Glutathione

Researcher Notes