Molecular Profile
What Is MOTS-c?
TypeMitochondrial-derived peptide
Amino Acids16
SequenceMRWQEMGYIFYPRKLR
Molecular Weight2,174.6 g/mol
FormulaC101H152N28O22S2
Encoded in12S rRNA (mtDNA)
⚠️ FOR RESEARCH PURPOSES ONLY — This compound is not FDA approved. All data presented is from clinical trials for educational reference.
Metabolic Peptide
MOTS-C
Mitochondrial ORF of the 12S rRNA type-cMRWQEMGYIFYPRKLR
A mitochondrial-derived peptide that modulates metabolic processes, with significant implications for exercise metabolism observed in rodent studies. Premium Research Peptide.
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MOTS-C$39.99
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Compound Information
Technical specifications
Cell Metabolism 2015
Storage Requirements
Stability Information
Extremely temperature sensitiveStore frozen until useReconstitute immediately before injection
Lyophilized (powder)
-20°C•stable long-term
Reconstituted
2-8°C•use immediately
Room temperature
Degrades 85-90% in 2-3 hrs
Sources & References
Peer-reviewed research
Cell Metabolism
The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance
2015•DOI: 10.1016/j.cmet.2015.02.009•PMID: 25738459
Lee C, Zeng J, Drew BG et al.
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Nature CommunicationsMOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis
2021•DOI: 10.1038/s41467-020-20790-0
Reynolds JC, Lai RW, Woodhead JST et al.
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Alzheimer's Drug Discovery FoundationMOTS-c Cognitive Vitality Report
2021
ADDF Aging and Alzheimer's Prevention Program
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Aging CellThe mitochondrial-derived peptide MOTS-c: a player in exceptional longevity?
2015•DOI: 10.1111/acel.12389•PMID: 26289118
Fuku N, Pareja-Galeano H, Zempo H et al.
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Physiol RepThe mitochondrial-derived peptide MOTS-c is a regulator of plasma metabolites and enhances insulin sensitivity
2019•PMID: 31293078
Kim S-J, Miller B, Mehta HH et al.
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Biochemical and Biophysical Research CommunicationsMitochondria related peptide MOTS-c suppresses ovariectomy-induced bone loss via AMPK activation
2016
Ming W, Lu G, Xin S et al.
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Pediatric DiabetesCirculating MOTS-c levels are decreased in obese male children and adolescents and associated with insulin resistance
2018
Du C, Zhang C, Wu W et al.
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ClinicalTrials.govStudy of CB4211 in Patients With Nonalcoholic Fatty Liver Disease (NAFLD) and Obesity
2019
CohBar, Inc.
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⚠️Important Research Notice
Not for human consumption. This product is sold exclusively for research and educational purposes. It is not intended to diagnose, treat, cure, or prevent any disease.
All clinical trial data and research findings presented on this page are sourced from peer-reviewed journals and official publications. They are provided for educational reference only and should not be interpreted as medical advice or product claims.
By purchasing this product, you confirm that you are a qualified researcher and will use it in accordance with all applicable laws and regulations.
