Molecular Profile
What Is IGF-1 LR3?
TypeSynthetic IGF-1 analog
CAS Number143045-27-6
Molecular Weight9,117.60 g/mol
Amino Acids83
FormulaC400H625N111O115S9
SequenceMFPAMPLSSL FVNGPRTLCG...
⚠️ FOR RESEARCH PURPOSES ONLY — This compound is not FDA approved. All data presented is from clinical trials for educational reference.
Growth Factor Analog Peptide
IGF-1 LR3
Long R3 IGF-1LR3-IGF-1Long Arginine 3-IGF-1CAS: 143045-27-6
An 83-amino acid synthetic analog of human insulin-like growth factor 1 with reduced binding protein affinity and extended half-life, studied for anabolic and tissue growth effects in preclinical research. Premium Research Peptide.
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1
$69.99
Dosage
Quantity
1
$69.99
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Compound Information
Technical specifications
PubChem Database
Structural Modifications
How It Differs from Native IGF-1
N-terminal extension+13 amino acids (MFPAMPLLSLFVN)
Position 3 substitutionGlu → Arg
Total length83 vs 70 amino acids
IGFBP affinityDramatically reduced
IGF-1R affinityRetained
Sources & References
Peer-reviewed research
Biochemical Journal
Insulin-like growth factor-I (IGF-I) and especially IGF-I variants are anabolic in dexamethasone-treated rats
1992•DOI: 10.1042/bj2820091•PMID: 1371669
Tomas FM, Knowles SE, Owens PC et al.
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Journal of EndocrinologySuperior potency of infused IGF-I analogues which bind poorly to IGF-binding proteins is maintained when administered by injection
1996•DOI: 10.1677/joe.0.1500077•PMID: 8708565
Tomas FM, Lemmey AB, Read LC, Ballard FJ
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Journal of EndocrinologyIGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms
2002•DOI: 10.1677/joe.0.1750019•PMID: 12379487
Mohan S, Baylink DJ
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American Journal of PathologyIGF-1 has plaque-stabilizing effects in atherosclerosis by altering vascular smooth muscle cell phenotype
2011•DOI: 10.1016/j.ajpath.2010.10.007•PMID: 21281823
von der Thüsen JH, Borensztajn KS, Moimas S et al.
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Journal of EndocrinologyLong R3 insulin-like growth factor-I (IGF-I) infusion stimulates organ growth but reduces plasma IGF-I, IGF-II and IGF binding protein concentrations in the guinea pig
1995•DOI: 10.1677/joe.0.1460247•PMID: 7561636
Conlon MA, Tomas FM, Owens PC et al.
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⚠️Important Research Notice
Not for human consumption. This product is sold exclusively for research and educational purposes. It is not intended to diagnose, treat, cure, or prevent any disease.
All clinical trial data and research findings presented on this page are sourced from peer-reviewed journals and official publications. They are provided for educational reference only and should not be interpreted as medical advice or product claims.
By purchasing this product, you confirm that you are a qualified researcher and will use it in accordance with all applicable laws and regulations.
